SILENCING OF NRF2 REDUCES THE EXPRESSION OF ALDH1A1 AND ALDH3A1 AND SENSITIZES TO 5-FU IN PANCREATIC CANCER CELLS

Silencing of NRF2 Reduces the Expression of ALDH1A1 and ALDH3A1 and Sensitizes to 5-FU in Pancreatic Cancer Cells

Pancreatic cancer remains an intractable cancer with a poor five-year survival rate, which requires new therapeutic modalities based on the biology of pancreatic oncogenesis.Nuclear factor E2 related factor-2 (NRF2), a key cytoprotective nuclear transcription factor, regulates antioxidant production, reduction, detoxification Dining Extension Table

read more


Omics Analysis for Dinoflagellates Biology Research

Dinoflagellates are important primary producers for marine ecosystems and are also responsible for certain essential components in human foods.However, they are also notorious for their ability to form harmful algal blooms, and cause shellfish poisoning.Although much work has been devoted to dinoflagellates in recent decades, our understanding of t

read more

Single-cell analysis reveals differences among iNKT cells colonizing peripheral organs and identifies Klf2 as a key gene for iNKT emigration

Abstract Invariant natural killer T cell (iNKT) subsets are differentially distributed in various immune organs.However, it remains unclear whether iNKT cells exhibit phenotypical and functional differences Ice Cream Cone Dispensers in different peripheral organs and how thymic iNKT cells emigrate to peripheral organs.Here, we used single-cell RNA-

read more